Calcium mobilization from mitochondria in synaptic transmitter release
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چکیده
منابع مشابه
Calcium mobilization from mitochondria in synaptic transmitter release
Mitochondria can rapidly accumulate and release Ca2+ upon cell stimulation. A paper by Yang and coworkers in this issue reports an unusual form of synaptic potentiation, dependent on Ca2+ release from mitochondria through the Na+/Ca2+ exchanger and triggered by Na+ entry through voltage-gated channels (Yang et al., 2003).
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The mechanism of transmitter release by intracellular Ca has been explored by recording presynaptic Ca concentration ([Ca2+]i) with Ca-sensitive fluorescent dyes and by controlling [Ca2+]i with photosensitive Ca chelators. [Ca2+]i decays slowly (in seconds) after presynaptic action potentials, while transmitter release lasts only a few ms after each spike at fast synapses. Simulations of Ca dif...
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A one-dimensional model of presynaptic calcium diffusion away from the membrane, with cytoplasmic binding, extrusion by a surface pump, and influx during action potentials, can account for the rapid decay of phasic transmitter release and the slower decay of synaptic facilitation following one spike, as well as the very slow decline in total free calcium observed experimentally. However, simula...
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Dolphin, A. C. and Scott, R. H. (1987) J. Physiol. (London) 386, 1-17 Holz, G. G., Rane, S. G. and Dunlap, K. (1986) Nature (London) 319,670-672 Scott, R. H. and Dolphin, A. C. (1986) Neurosci. Lett. 69,59-64 Lewis, D. L., Weight, F. F. and Luini, A. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 9035-9039 Grassi, F. and Lux, H. D. (1989) Neurosci. Lett. 105, 113-1 19 Dolphin, A. C., Huston, E. and S...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200309111